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Sorting out “non‐canonical” autophagy

Authors
  • Fracchiolla, Dorotea1
  • Martens, Sascha1
  • 1 University of Vienna, Austria , (Austria)
Type
Published Article
Journal
The EMBO Journal
Publisher
EMBO
Publication Date
Feb 05, 2018
Volume
37
Issue
4
Identifiers
DOI: 10.15252/embj.201798895
PMID: 29431607
PMCID: PMC5813255
Source
PubMed Central
Keywords
License
Unknown
External links

Abstract

Canonically, LC 3 lipidation has been associated with autophagy pathways but it becomes increasingly clear that this modification can also occur during autophagy‐unrelated processes. In this issue, Florey and colleagues find that the WD 40 domain of ATG 16L1 is dispensable for LC 3 lipidation during starvation‐induced autophagy but required for its lipidation during several other membrane‐based processes that are different from autophagy. This finding opens the door for the analysis of the functions of LC 3 lipidation in these pathways.

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