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Sorafenib stimulates human skin type mast cell degranulation and maturation.

Authors
  • Mizukami, Yukari1
  • Sugawara, Koji2
  • Kira, Yukimi3
  • Tsuruta, Daisuke1
  • 1 Department of Dermatology, Osaka City University Graduate School of Medicine, Osaka, Japan. , (Japan)
  • 2 Department of Dermatology, Osaka City University Graduate School of Medicine, Osaka, Japan. Electronic address: [email protected] , (Japan)
  • 3 Department of Central Laboratory, Osaka City University Graduate School of Medicine, Osaka, Japan. , (Japan)
Type
Published Article
Journal
Journal of dermatological science
Publication Date
Dec 01, 2017
Volume
88
Issue
3
Pages
308–319
Identifiers
DOI: 10.1016/j.jdermsci.2017.08.005
PMID: 28843624
Source
Medline
Keywords
License
Unknown

Abstract

Our results contribute to a better understanding of the mechanism by which sorafenib induces adverse cutaneous reactions via activation of skin-type MC degranulation and maturation. This activation appears to be related to PI3K signaling and SCF production, which could be a new targets for treating sorafenib-induced adverse reactions.

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