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Sonication, calcium, and peptides have systematic effects on the nonlinear dynamics of tyrosine hydroxylase activity.

Authors
  • Russo, P V
  • Mandell, A J
Type
Published Article
Journal
Neurochemistry International
Publisher
Elsevier
Publication Date
Jan 01, 1986
Volume
9
Issue
1
Pages
171–176
Identifiers
PMID: 20493114
Source
Medline
License
Unknown

Abstract

Sonication, dialysis, calcium, and peptides have systematic effects on the nonlinear dynamics of tyrosine hydroxylase (TOH). Under standard assay conditions TOH shows a high amplitude fluctuation in catalytic output across time that is eliminated either by sonication or by dialysis. This coherent dynamic is restored with the addition to the dialyzed preparation of either calcium in micromolar concentrations or certain peptides (SOM, MSH), but not others (CCK, TRH).

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