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Sonic hedgehog, BMP4, and Hox genes in the development of anorectal malformations in Ethylenethiourea-exposed fetal rats.

Authors
  • Mandhan, Parkash
  • Quan, Qi Bao
  • Beasley, Spencer
  • Sullivan, Michael
Type
Published Article
Journal
Journal of Pediatric Surgery
Publisher
Elsevier
Publication Date
Dec 01, 2006
Volume
41
Issue
12
Pages
2041–2045
Identifiers
PMID: 17161201
Source
Medline
License
Unknown

Abstract

This study shows that ETU disturbs the expression of shh signaling pathway during the development of hindgut. We provide evidence that shh plays a pivotal role in the hindgut morphogenesis, and its misexpression affect the expression of targets, BMP4 and Hox genes.

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