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Something Else to Stress about: Perinatal Stress Attenuates CD8 + T Cell Activity in Adults

Authors
  • Avishai, Eden1
  • Rolls, Asya1
  • 1 Rappaport Faculty of Medicine, Technion—Israel Institute of Technology, Haifa, Israel
Type
Published Article
Journal
Immunity
Publication Date
Apr 14, 2020
Volume
52
Issue
4
Pages
580–582
Identifiers
DOI: 10.1016/j.immuni.2020.03.014
PMID: 32294404
PMCID: PMC7194811
Source
PubMed Central
License
Unknown

Abstract

Early-life stress has adverse health effects, but the underlying mechanisms are unclear. Hong et al. demonstrate that perinatal exposure to glucocorticoids in mice reprograms the neuroendocrine stress pathway. This results in reduced glucocorticoid levels in adults, leading to attenuated anti-tumor and anti-bacterial CD8+ T cell responses.

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