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Some haemorheological factors in patients with arteriosclerosis obliterans after treatment of trental.

Authors
Type
Published Article
Journal
Folia haematologica (Leipzig, Germany : 1928)
Publication Date
Volume
114
Issue
4
Pages
549–554
Identifiers
PMID: 2446996
Source
Medline
License
Unknown

Abstract

Erythrocytes deformability, plasma cAMP, 6-keto-PGF1 alpha, TXB2 levels and fibrinolytic activity in patients suffering from arteriosclerosis obliterans before and after Trental were studied. Trental improved the deformability of red cells and resulted in an enhancement of diminished cAMP level in plasma and increased the fibrinolytic activity. The improvement of deformability observed after Trental could depend upon the influence of a higher cAMP level in plasma on the erythrocyte membrane. The increase of cAMP level seems to be the result of the inhibiting effect of Trental on phosphodiesterase and of higher fibrinolytic activity.

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