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Some evidence for the involvement of adrenergic sites in the memory trace.

Authors
  • Roberts, R B
  • Flexner, J B
  • Flexner, L B
Type
Published Article
Journal
Proceedings of the National Academy of Sciences of the United States of America
Publication Date
Jun 01, 1970
Volume
66
Issue
2
Pages
310–313
Identifiers
PMID: 5271166
Source
Medline
License
Unknown

Abstract

Puromycin was injected bitemporally in mice one day after training in a Y-maze. Eight days later various psychotropic drugs were injected intraperitoneally or subcutaneously at maximum tolerable doses. Ten days after the drug injection the mice were tested for their memory of the maze-learning. Memory was lost in control animals injected with saline but restored in most of the animals injected with imipramine, tranylcypromine, or D-amphetamine. Some indication of restoration was observed after injection of reserpine or L-dopa. These results suggest that the blockage caused by puromycin is due to adsorption of peptidyl-puromycin to adrenergic sites and that these sites may be involved in the memory trace.

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