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Some comparative aspects of the pharmacokinetics of tylosin in buffaloes and cattle.

Authors
  • Saurit, A R
  • Rubio, M
  • Baroni, E
  • San, Andrés M
  • Sánchez, S
  • Boggio, J C
Type
Published Article
Journal
Veterinary research communications
Publication Date
Jan 01, 2002
Volume
26
Issue
1
Pages
49–54
Identifiers
PMID: 11860087
Source
Medline
License
Unknown

Abstract

The pharmacokinetics of tylosin were compared in cattle (Bos taurus) and buffaloes (Bubalus bubalis). Six animals received each a single dose of 10 mg/kg of tylosin tartrate by the intramuscular route. The serum concentration (Cmax) and the volume of distribution (Vd) presented significant differences between the two species. Cmax was 0.40 +/- 0.046 microg/ml for buffaloes and 0.64 +/- 0.068 microg/ml for cattle. Vd was 1.91 +/- 0.12 L/kg and 1.33 +/- 0.09 L/kg for buffaloes and cattle, respectively. However, as the present study did not show considerable differences in the pharmacokinetics of tylosin in buffaloes and cattle, similar dosage regimes of this drug can be recommended for both species.

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