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Some behavioral effects of chlorodesmethyldiazepam and lorazepam.

Authors
  • Kostowski, W
  • Płaźnik, A
  • Puciłowski, O
  • Trzaskowska, E
  • Lipińska, T
Type
Published Article
Journal
Polish journal of pharmacology and pharmacy
Publication Date
Jan 01, 1981
Volume
33
Issue
6
Pages
597–602
Identifiers
PMID: 6127668
Source
Medline
License
Unknown

Abstract

Two benzodiazepine derivatives, chlorodesmethyldiazepam (CDD) and lorazepam (LOR) were compared in rats and mice in some behavioral tests. Both compounds similarly depressed audiogenic seizures, facilitated the behavior suppressed by punishment (conflict test) and produced muscle relaxant and sedative effects as measured in a rota-rod test. In low and moderate doses CDD paradoxically increased shock-induced fighting while in a higher dose it strongly reduced this behavioral pattern.

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