Affordable Access

Some aspects of the pharmacology of beta-adrenorecptor blockers.

Authors
  • Ablad, B
  • Carlsson, E
  • Dahlŏf, C
  • Ek, L
Type
Published Article
Journal
Drugs
Publication Date
Jan 01, 1976
Volume
11 SUPPL 1
Pages
100–111
Identifiers
PMID: 6242
Source
Medline
License
Unknown

Abstract

The pharmacodynamic properties of a beta-blocker are mainly determined by its affinity to beta1 and beta2-receptors respectively and by its intrinsic activity. It is suggested that there is no absolute organ separation of the two receptor sub-types. Instead both beta1 and beta2-receptors are involved in the mediation of the same effect. The frequency distribution ratio of beta1/beta2-receptors varied markedly among various effector responses. A non-selective and a beta1-selective blocker may have different haemodynamic effects when the levels of circulating adrenaline are high, because of their markedly different potency in inhibiting the beta2-mediated vasodilator effect of adrenaline. Data are presented which suggest the existence of a presynaptic beta1-receptor mediating a positive feedback mechanism on neuronal release of noradrenaline.

Report this publication

Statistics

Seen <100 times