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Somatic Mutagenesis in Mammals and Its Implications for Human Disease and Aging

Authors
  • Zhang, Lei
  • Vijg, Jan
Type
Published Article
Journal
Annual Review of Genetics
Publisher
Annual Reviews
Publication Date
Nov 23, 2018
Volume
52
Pages
397–419
Identifiers
DOI: 10.1146/annurev-genet-120417-031501
Source
Annual Reviews
Keywords
License
Yellow

Abstract

DNA mutations as a consequence of errors during DNA damage repair, replication, or mitosis are the substrate for evolution. In multicellular organisms, mutations can occur in the germline and also in somatic tissues, where they are associated with cancer and other chronic diseases and possibly with aging. Recent advances in high-throughput sequencing have made it relatively easy to study germline de novo mutations, but in somatic cells, the vast majority of mutations are low-abundant and can be detected only in clonal lineages, such as tumors, or single cells. Here we review recent results on somatic mutations in normal human and animal tissues with a focus on their possible functional consequences.

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