Affordable Access

deepdyve-link
Publisher Website

Solvothermal-assisted in situ rapid growth of octadecylamine functionalized polydopamine-based permanent coating as stationary phase for open-tubular capillary electrochromatography.

Authors
  • Yi, Gaoyi1
  • He, Jingxia2
  • Ji, Baian1
  • Gao, Die1
  • Zhang, Kailian1
  • Wang, Lujun1
  • Zeng, Jing1
  • Xia, Zhining3
  • Fu, Qifeng4
  • 1 School of Pharmacy, Southwest Medical University, Luzhou 646000, China. , (China)
  • 2 Research Institute of Chinese Medicine, Shaanxi institute of international trade & commerce, Xianyang 712000, China. , (China)
  • 3 School of Pharmaceutical Sciences, Chongqing University, Chongqing 401331, China. Electronic address: [email protected] , (China)
  • 4 School of Pharmacy, Southwest Medical University, Luzhou 646000, China. Electronic address: [email protected] , (China)
Type
Published Article
Journal
Journal of chromatography. A
Publication Date
Sep 27, 2020
Volume
1628
Pages
461436–461436
Identifiers
DOI: 10.1016/j.chroma.2020.461436
PMID: 32822976
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

In recent years, mussel-inspired polydopamine (PDA) based materials have been widely used as stationary phases for open-tubular capillary electrochromatography (OT-CEC) because of their various excellent properties. Nevertheless, the traditional synthesis routes of functionalized PDA-based capillary columns usually are time-consuming and limited in aqueous solutions. Herein, we report a facile and rapid route to prepare octadecylamine (ODA) functionalized PDA coated OT-CEC columns in organic solvents via a novel one-step in situ solvothermal-assisted coating strategy. Through this developed solvothermal-assisted approach, the growth rate of ODA/PDA coating was significantly speeded up and their hybrid coating process on the capillary inner surface could be rapidly completed in 60 min. The successful preparation of the solvothermal-assisted ODA/PDA hybrid coating were systematically characterized and confirmed by several methods. The influence of the preparation parameters on the formation of hybrid coating and the separation ability of the ODA/PDA modified columns were systematically explored. Consequently, the high-efficiency baseline separation of four kinds of neutral, acidic and basic analytes were achieved based on the ODA/PDA modified columns. The repeatability of the solvothermal-assisted ODA/PDA coated column was also studied, and the relative standard deviations for intra-day, inter-day and column-to-column were all less than 5%. Additionally, the solvothermal-assisted ODA/PDA modified column exhibited good stability and long lifetime. Copyright © 2020 Elsevier B.V. All rights reserved.

Report this publication

Statistics

Seen <100 times