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Solvent stable microbial lipases: current understanding and biotechnological applications

Authors
  • Priyanka, Priyanka1
  • Tan, Yeqi1
  • Kinsella, Gemma K.1
  • Henehan, Gary T.1
  • Ryan, Barry J.1
  • 1 Dublin Institute of Technology, Dublin 1, Ireland , Dublin 1 (Ireland)
Type
Published Article
Journal
Biotechnology Letters
Publisher
Springer-Verlag
Publication Date
Dec 07, 2018
Volume
41
Issue
2
Pages
203–220
Identifiers
DOI: 10.1007/s10529-018-02633-7
Source
Springer Nature
Keywords
License
Yellow

Abstract

ObjectiveThis review examines on our current understanding of microbial lipase solvent tolerance, with a specific focus on the molecular strategies employed to improve lipase stability in a non-aqueous environment.ResultsIt provides an overview of known solvent tolerant lipases and of approaches to improving solvent stability such as; enhancing stabilising interactions, modification of residue flexibility and surface charge alteration. It shows that judicious selection of lipase source supplemented by appropriate enzyme stabilisation, can lead to a wide application spectrum for lipases.ConclusionOrganic solvent stable lipases are, and will continue to be, versatile and adaptable biocatalytic workhorses commonly employed for industrial applications in the food, pharmaceutical and green manufacturing industries.

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