Soluble RAGE but not endogenous secretory RAGE is associated with albuminuria in patients with type 2 diabetes

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Soluble RAGE but not endogenous secretory RAGE is associated with albuminuria in patients with type 2 diabetes

Publisher
BioMed Central
Publication Date
Mar 07, 2007
Source
PMC
Keywords
Disciplines
  • Biology
  • Medicine
License
Unknown

Abstract

1475-2840-6-9.fm ral ss BioMed CentCardiovascular Diabetology Open AcceOriginal investigation Soluble RAGE but not endogenous secretory RAGE is associated with albuminuria in patients with type 2 diabetes Per M Humpert, Zdenka Djuric, Stefan Kopf, Gottfried Rudofsky, Michael Morcos, Peter P Nawroth and Angelika Bierhaus* Address: Department of Medicine I and Clinical Chemistry, University of Heidelberg, Germany Email: Per M Humpert - [email protected].de; Zdenka Djuric - [email protected]; Stefan Kopf - [email protected]; Gottfried Rudofsky - [email protected]; Michael Morcos - [email protected]; Peter P Nawroth - [email protected]; Angelika Bierhaus* - [email protected] * Corresponding author Abstract Background: Total circulating soluble receptor for advanced glycation endproducts (sRAGE) and a more defined endogenous secretory splice variant of the receptor (esRAGE) were shown to be associated with different markers of cardiovascular risk in patients with diabetes. Since previous data were partly divergent, the aim of this study was to compare sRAGE and esRAGE in a head- to-head analysis in patients with type 2 diabetes (T2DM) with albuminuria. Methods: sRAGE and esRAGE were studied in plasma of 110 T2DM patients using enzyme-linked immunosorbant assays (ELISA) detecting either sRAGE or esRAGE only. Both sRAGE and esRAGE were compared with regard to applicability as markers for vascular disease and glucose control in T2DM. Results: In bivariate analysis, sRAGE correlated with age (R = 0.22, p = 0.02) and the 24 hour albumin excretion rate (R = 0.18, p = 0.05), while esRAGE correlated positively with age only (R = 0.23, p = 0.02). In contrast to previous reports, neither sRAGE nor esRAGE correlated with glucose control or intima-media-thickness (IMT) as a predictor of macrovascular disease. In multivariate regression models, the associa

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