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Soluble CD44 is a potential marker for the early detection of head and neck cancer.

Authors
  • Franzmann, Elizabeth J1
  • Reategui, Erika P
  • Pedroso, Felipe
  • Pernas, Francisco G
  • Karakullukcu, Baris M
  • Carraway, Kermit L
  • Hamilton, Kara
  • Singal, Rakesh
  • Goodwin, W Jarrard
Type
Published Article
Journal
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
Publication Date
Jul 01, 2007
Volume
16
Issue
7
Pages
1348–1355
Identifiers
PMID: 17627000
Source
Medline
License
Unknown

Abstract

SolCD44 is elevated in the majority of HNSCC and distinguishes cancer from benign disease with high specificity. Whereas the solCD44 test lacks sensitivity by itself, methylation status of the CD44 gene seems to complement the solCD44 test. Our pilot data indicate that, together, these markers will detect HNSCC with very high sensitivity and specificity.

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