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Soluble ACE2-mediated cell entry of SARS-CoV-2 via interaction with proteins related to the renin-angiotensin system

Authors
  • Yeung, Man Lung1, 2, 3, 4
  • Teng, Jade Lee Lee1, 3, 4
  • Jia, Lilong3
  • Zhang, Chaoyu3
  • Huang, Chengxi3
  • Cai, Jian-Piao3
  • Zhou, Runhong3, 5
  • Chan, Kwok-Hung1, 2, 3
  • Zhao, Hanjun1, 3, 4
  • Zhu, Lin6
  • Siu, Kam-Leung7
  • Fung, Sin-Yee7
  • Yung, Susan8
  • Chan, Tak Mao8
  • To, Kelvin Kai-Wang1, 2, 3, 4
  • Chan, Jasper Fuk-Woo1, 2, 3, 4
  • Cai, Zongwei6
  • Lau, Susanna Kar Pui1, 3, 4
  • Chen, Zhiwei1, 2, 3, 4, 5
  • Jin, Dong-Yan7
  • And 2 more
  • 1 State Key Laboratory of Emerging Infectious Diseases, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, China
  • 2 Department of Clinical Microbiology and Infection Control, The University of Hong Kong-Shenzhen Hospital, Shenzhen, Guangdong Province, China
  • 3 Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, China
  • 4 Carol Yu Centre for Infection, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, China
  • 5 AIDS Institute, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, China
  • 6 State Key Laboratory of Environmental and Biological Analysis, Department of Chemistry, Hong Kong Baptist University, Hong Kong Special Administrative Region, China
  • 7 Department of Biochemistry, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, China
  • 8 Department of Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, China
Type
Published Article
Journal
Cell
Publisher
Elsevier Inc.
Publication Date
Mar 02, 2021
Identifiers
DOI: 10.1016/j.cell.2021.02.053
PMCID: PMC7923941
Source
PubMed Central
Keywords
License
Unknown

Abstract

Using an infection-permissive human kidney cell line, Yeung et al. show that a soluble form of ACE2 that is cleaved and liberated from the host cell surface mediates SARS-CoV-2 binding and uptake by receptors involved in renin-angiotensin system signaling.

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