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Solubilization and stabilization of macular carotenoids by water soluble oligosaccharides and polysaccharides.

Authors
  • Apanasenko, Irina E1
  • Selyutina, Olga Yu1
  • Polyakov, Nikolay E2
  • Suntsova, Lyubov P3
  • Meteleva, Elizaveta S3
  • Dushkin, Alexander V3
  • Vachali, Preejith4
  • Bernstein, Paul S4
  • 1 Institute of Chemical Kinetics and Combustion, Novosibirsk, Russia; Novosibirsk State University, Novosibirsk, Russia.
  • 2 Institute of Chemical Kinetics and Combustion, Novosibirsk, Russia. Electronic address: [email protected]
  • 3 Institute of Solid State Chemistry and Mechanochemistry, Novosibirsk, Russia.
  • 4 Department of Ophthalmology and Visual Sciences, Moran Eye Center, University of Utah School of Medicine, Salt Lake City, UT, USA.
Type
Published Article
Journal
Archives of Biochemistry and Biophysics
Publisher
Elsevier
Publication Date
Apr 15, 2015
Volume
572
Pages
58–65
Identifiers
DOI: 10.1016/j.abb.2014.12.010
PMID: 25527162
Source
Medline
Keywords
License
Unknown

Abstract

Xanthophyll carotenoids zeaxanthin and lutein play a special role in the prevention and treatment of visual diseases. These carotenoids are not produced by the human body and must be consumed in the diet. On the other hand, extremely low water solubility of these carotenoids and their instability restrict their practical application as components of food or medicinal formulations. Preparation of supramolecular complexes of zeaxanthin and lutein with glycyrrhizic acid, its disodium salt and the natural polysaccharide arabinogalactan allows one to minimize the aforementioned disadvantages when carotenoids are used in food processing as well as for production of therapeutic formulations with enhanced solubility and stability. In the present study, the formation of supramolecular complexes was investigated by NMR relaxation, surface plasmon resonance (SPR) and optical absorption techniques. The complexes increase carotenoid solubility more than 1000-fold. The kinetics of carotenoid decay in reactions with ozone molecules, hydroperoxyl radicals and metal ions were measured in water and organic solutions, and significant increases in oxidation stability of lutein and zeaxanthin in arabinogalactan and glycyrrhizin complexes were detected.

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