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Solid-phase synthesis of 1,7-disubstituted-1,3,5-triazepane-2,4-diones.

Authors
Type
Published Article
Journal
Organic Letters
1523-7052
Publisher
American Chemical Society
Publication Date
Volume
3
Issue
18
Pages
2797–2799
Identifiers
PMID: 11529759
Source
Medline
License
Unknown

Abstract

[reaction: see text]. The solid-phase synthesis of 1,7-disubstituted-1,3,5-triazepane-2,4-diones from resin-bound amino acids is described. The exhaustive reduction of solid-support bound amides with borane afforded the requisite secondary amines, which following treatment with phenyl isocyanatoformate and cleavage, provided the corresponding triazepane-2,4-diones.

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