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The snowdrop, wellspring of galanthamine : A brief descriptive and scientific history.

Authors
  • Cozanitis, Dimitri A1
  • 1 Department of Anaesthesiology, Intensive Care and Pain Medicine, University of Helsinki and Helsinki University Hospital, Haartmaninkatu 4, PO Box 340, 00290 HUS, Helsinki, Finland. [email protected] , (Finland)
Type
Published Article
Journal
Wiener medizinische Wochenschrift (1946)
Publication Date
Jun 01, 2021
Volume
171
Issue
9-10
Pages
205–213
Identifiers
DOI: 10.1007/s10354-020-00799-2
PMID: 33502637
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

A history of the common snowdrop, Galanthus nivalis, is set out in folkloric fashion. Its religious connection is evident as well as the inspiration it arouses in artists and in ordinary persons. It is intended to shed light on the initial works relating to the snowdrop's alkaloid, galanthamine, performed by Soviet and Bulgarian scientists, which lie buried away and generally remain unknown. A brief history and nature of alkaloids continues with the emphasis placed on galanthamine. Heretofore hidden uses of snowdrops in traditional (folk) medicine are unveiled. An anticholinesterase with central and peripheral activity, feasible clinical indications with galanthamine are described. Certain disorders for which galanthamine has been deemed beneficial are presented for their historical value. Ongoing research regarding drugs and chemicals developed from the snowdrop and galanthamine is mentioned.

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