Affordable Access

deepdyve-link
Publisher Website

Snail transcription factors in hematopoietic cell development: a model of functional redundancy

Authors
  • Pioli, Peter D.
  • Weis, John H.1, 2, 3
  • 1 Division of Cell Biology and Immunology
  • 2 Department of Pathology
  • 3 University of Utah
Type
Published Article
Journal
Experimental Hematology
Publisher
Elsevier
Publication Date
Jan 01, 2014
Accepted Date
Mar 07, 2014
Identifiers
DOI: 10.1016/j.exphem.2014.03.002
Source
Elsevier
Keywords
License
Unknown

Abstract

Coordinated gene expression is crucial in facilitating proper lymphoid cell development and function. The precise patterns of gene expression during B and T cell development are regulated through a complex interplay between a multitude of transcriptional regulators, both activators and repressors. We have recently identified the Snail family of transcription factors as playing significant and overlapping roles in lymphoid cell development in that deletion of both Snai2 and Snai3 was required to fully impact the generation of mature T and B cells. Analyses using compound heterozygote animals further demonstrated that Snai2 and Snai3 were partially haplo-sufficient and relatively equivalent in their ability to preserve B cell generation in the bone marrow. In this review, we summarize studies elucidating the role(s) of the Snail family in hematopoiesis with a focus on lymphoid cell development. Using the Snail family as an example, we discuss the concepts of functional redundancy and strategies employed to assay transcription factor families for “intra-member” compensation.

Report this publication

Statistics

Seen <100 times