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Smoking-induced aggravation of experimental arthritis is dependent of aryl hydrocarbon receptor activation in Th17 cells

Authors
  • Talbot, Jhimmy
  • Peres, Raphael Sanches
  • Pinto, Larissa G.
  • Oliveira, Rene D. R.
  • Lima, Kalil A.
  • Donate, Paula B.
  • Silva, Jaqueline R.
  • Ryffel, Bernard
  • Cunha, Thiago M.
  • Alves Filho, José C.
  • Liew, Foo Y.
  • Louzada Junior, Paulo
  • Cunha, Fernando de Queiroz
Publication Date
Jun 10, 2018
Source
Biblioteca Digital da Produção Intelectual da Universidade de São Paulo (BDPI/USP)
Keywords
Language
English
License
Unknown
External links

Abstract

The research leading to these results received funding from the European Union Seventh Framework Programme [FP7–2007-2013] under grant agreement number HEALTH-F4–2011-281608 (TIMER), from the São Paulo Research Foundation (FAPESP) under grant agreements number 2011/19670–0 (Projeto Temático) and 2013/08216–2 (Center for Research in Inflammatory Fig. 4 AHR activation in T cells induces arthritis aggravation in an IL-17RA-dependent manner. a AIA was induced in WT or Il17ra−/− mice and treated with vehicle or FICZ (90 μg/kg) during immunization. Neutrophil in the joints and hyperalgesia were determined 7 h after challenge. Mean ± SEM, n = 5/group, * P < 0.05; n.s, not significant, one-way ANOVA followed by Bonferroni post hoc test. b AIA was induced in WT mice treated with anti-IL-17 (α-IL-17) or the isotype control antibody at the same time as the mice were treated with vehicle or FICZ. Neutrophil in the joints and hyperalgesia were determined 7 h after challenge. Mean ± SEM, n = 5/group, * P < 0.05; n.s, not significant, one-way ANOVA followed by Bonferroni post hoc test. c AIA was induced in WT or Ahr−/− mice. The mice were treated or not with FICZ. One group of Ahr−/− mice (CD4+ WT cells → Ahr−/− ) received CD4+ T cells from WT mice 1 day before the first immunization. Data are mean ± SEM, n = 5/group, * P < 0.05, **P < 0.01, ***P < 0.001, one-way ANOVA followed by Bonferroni post hoc test. All data are representative of two independent experiments. DLN draining lymph nodes, FICZ 6-formylindolo[3,2-b]carbazole, IL-17 interleukin 17 Talbot et al. Arthritis Research & Therapy (2018) 20:119 Page 9 of 11 Disease) and from the University of São Paulo NAP-DIN under grant agreement number 11.1.21625.01.0.

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