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Smoking and Parkinson disease: Evidence for gene-by-smoking interactions.

Authors
  • Lee, Pei-Chen1
  • Ahmed, Ismaïl1
  • Loriot, Marie-Anne1
  • Mulot, Claire1
  • Paul, Kimberly C1
  • Bronstein, Jeff M1
  • Ritz, Beate1
  • Elbaz, Alexis2
  • 1 From the Department of Health Care Management (P.-C.L.), College of Health Technology, National Taipei University of Nursing and Health Sciences, Taiwan; Biostatistics, Biomathematics, Pharmacoepidemiology and Infectious Diseases (I.A.), INSERM, UVSQ, Institut Pasteur, Université Paris-Saclay, Villejuif; Assistance-Publique-Hôpitaux de Paris (M.-A.L.), Hôpital Européen Georges Pompidou, Biochimie, Pharmacogénétique et Oncologie Moléculaire; INSERM UMR-S 1147 (C.M.), CRB EPIGENETEC, Université Paris Descartes, Sorbonne Paris Cité, Paris, France; Departments of Epidemiology (K.C.P., B.R.) and Environmental Health (J.M.B., B.R.), Fielding School of Public Health, and Department of Neurology (J.M.B., B.R.), Geffen School of Medicine, University of California at Los Angeles; and Université Paris-Saclay (A.E.), Université Paris-Sud, UVSQ, CESP, INSERM, Villejuif, France. , (France)
  • 2 From the Department of Health Care Management (P.-C.L.), College of Health Technology, National Taipei University of Nursing and Health Sciences, Taiwan; Biostatistics, Biomathematics, Pharmacoepidemiology and Infectious Diseases (I.A.), INSERM, UVSQ, Institut Pasteur, Université Paris-Saclay, Villejuif; Assistance-Publique-Hôpitaux de Paris (M.-A.L.), Hôpital Européen Georges Pompidou, Biochimie, Pharmacogénétique et Oncologie Moléculaire; INSERM UMR-S 1147 (C.M.), CRB EPIGENETEC, Université Paris Descartes, Sorbonne Paris Cité, Paris, France; Departments of Epidemiology (K.C.P., B.R.) and Environmental Health (J.M.B., B.R.), Fielding School of Public Health, and Department of Neurology (J.M.B., B.R.), Geffen School of Medicine, University of California at Los Angeles; and Université Paris-Saclay (A.E.), Université Paris-Sud, UVSQ, CESP, INSERM, Villejuif, France. [email protected] , (France)
Type
Published Article
Journal
Neurology
Publisher
Ovid Technologies (Wolters Kluwer) - American Academy of Neurology
Publication Date
Feb 13, 2018
Volume
90
Issue
7
Identifiers
DOI: 10.1212/WNL.0000000000004953
PMID: 29352099
Source
Medline
License
Unknown

Abstract

We identified and replicated suggestive gene-by-smoking interactions in PD. The inverse association of smoking with PD was less pronounced in carriers of minor alleles of both RXRA-rs4240705 and SLC17A6-rs1900586. These findings may help identify biological pathways involved in the inverse association between smoking and PD.

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