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Smoking and Male Gender Rather than CagA Protein Are Associated with Increased Risk for Duodenal Ulcer in Helicobacter pylori-Infected Patients in Taiwan

Authors
  • Chen, Tseng-Shing
  • Chang, Full-Young
  • Lee, Shou-Dong
Type
Published Article
Journal
Digestive Diseases and Sciences
Publisher
Springer-Verlag
Publication Date
Oct 01, 1999
Volume
44
Issue
10
Pages
2076–2080
Identifiers
DOI: 10.1023/A:1026634721351
Source
Springer Nature
Keywords
License
Yellow

Abstract

The aim of this study was to examine theseroprevalence of antibody to CagA antigen, as well asother major H. pylori antigens by Western blot in H.pylori-infected subjects with endoscopically normal mucosa (N = 54) and duodenal ulcer (N = 51).The role of the host and environmental factors was alsoevaluated. There was no significant difference in theprevalence of antibodies against the major H. pylori antigens between the two groups. A highprevalence of antibody to CagA was detected in patientswith normal mucosa (93%) and duodenal ulcer (86%).Multivariate analysis shows that male gender (odds ratio= 4.94, 95% CI = 1.39-17.77, P = 0.014) and smoking(odds ratio = 8.89, 95% CI = 2.17-36.48, P = 0.002) wereassociated with duodenal ulcer disease. This studysuggests that smoking and male gender rather than CagA protein are associated with increasedrisk for duodenal ulcer in H. pylori-infected patientsin Taiwan.

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