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Smoking-induced upregulation of AKR1B10 expression in the airway epithelium of healthy individuals.

Authors
  • Wang, Rui
  • Wang, Guoqing
  • Ricard, Megan J
  • Ferris, Barbara
  • Strulovici-Barel, Yael
  • Salit, Jacqueline
  • Hackett, Neil R
  • Gudas, Lorraine J
  • Crystal, Ronald G
Type
Published Article
Journal
CHEST Journal
Publisher
Elsevier
Publication Date
Dec 01, 2010
Volume
138
Issue
6
Pages
1402–1410
Identifiers
DOI: 10.1378/chest.09-2634
PMID: 20705797
Source
Medline
License
Unknown

Abstract

Smoking per se mediates upregulation of AKR1B10 expression in the airway epithelia of healthy smokers with no evidence of lung cancer. In the context of these observations and the link of AKR1B10 to the metabolism of retinals and to lung cancer, the smoking-induced upregulation of AKR1B10 may be an early process in the multiple events leading to lung cancer.

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