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A smart and versatile theranostic nanomedicine platform based on nanoporphyrin.

Authors
  • Yuanpei Li
  • Ty, Lin
  • Y, Luo
  • Q, Liu
  • Wenwu Xiao
  • W, Guo
  • D, Lac
  • H, Zhang
  • C, Feng
  • S, Wachsmann-Hogiu
  • Jh, Walton
  • Sr, Cherry
  • Dj, Rowland
  • D, Kukis
  • C, Pan
  • Kit S. Lam
Type
Published Article
Journal
Nature Communications
Publisher
Springer Nature
Volume
5
Pages
4712–4712
Identifiers
DOI: 10.1038/ncomms5712
Source
Kit Lam Lab
License
Unknown

Abstract

Multifunctional nanoparticles with combined diagnostic and therapeutic functions show great promise towards personalized nanomedicine. However, attaining consistently high performance of these functions in vivo in one single nanoconstruct remains extremely challenging. Here we demonstrate the use of one single polymer to develop a smart all-in-one nanoporphyrin platform that conveniently integrates a broad range of clinically relevant functions. Nanoporphyrins can be used as amplifiable multimodality nanoprobes for near-infrared fluorescence imaging (NIRFI), magnetic resonance imaging (MRI), positron emission tomography (PET) and dual modal PET-MRI. Nanoporphyrins greatly increase the imaging sensitivity for tumour detection through background suppression in blood, as well as preferential accumulation and signal amplification in tumours. Nanoporphyrins also function as multiphase nanotransducers that can efficiently convert light to heat inside tumours for photothermal therapy (PTT), and light to singlet oxygen for photodynamic therapy (PDT). Furthermore, nanoporphyrins act as programmable releasing nanocarriers for targeted delivery of drugs or therapeutic radio-metals into tumours.

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