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SMARCA4-deficient lung tumour that presented with haemoptysis and progressed rapidly.

Authors
  • Inoue, Mari1
  • Enomoto, Tatsuji1
  • Kawamoto, Masashi2
  • Mikami, Naoto1
  • Kuribayashi, Hidehiko1
  • Saeki, Noriyuki1
  • 1 Department of Respiratory Disease Center Ofuna Chuo Hospital Kamakura Japan. , (Japan)
  • 2 Department of Diagnostic Pathology Teikyo University Hospital, Mizonokuchi Kawasaki Japan. , (Japan)
Type
Published Article
Journal
Respirology case reports
Publication Date
Oct 01, 2020
Volume
8
Issue
7
Identifiers
DOI: 10.1002/rcr2.656
PMID: 32884816
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

The case of a heavy ex-smoking man in his early 70s who presented with haemoptysis and died following rapid progression is presented. The tumour excised by surgery was mostly composed of monotonous large rhabdoid cells showing prominent nucleoli and eosinophilic cytoplasm. On immunohistochemistry with SMARCA4 (BRG-1), the tumour cells showed significant loss of expression. The tumour was diagnosed as a SMARCA4-deficient thoracic sarcoma. This is a disease that progresses rapidly and has a poor prognosis. However, the search for specific treatments using synthetic lethality is underway. Clinical and pathological characteristics can be identified with examination of more cases, and when the tumour is suspected, it is necessary to actively perform immunohistochemical examination. © 2020 The Authors. Respirology Case Reports published by John Wiley & Sons Australia, Ltd on behalf of The Asian Pacific Society of Respirology.

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