Affordable Access

deepdyve-link
Publisher Website

The small subunit processome in ribosome biogenesis—progress and prospects.

Authors
  • Phipps, Kathleen R
  • Charette, J Michael
  • Baserga, Susan J
Type
Published Article
Journal
Wiley Interdisciplinary Reviews - RNA
Publisher
Wiley (John Wiley & Sons)
Publication Date
Jan 01, 2011
Volume
2
Issue
1
Pages
1–21
Identifiers
DOI: 10.1002/wrna.57
PMID: 21318072
Source
Medline
Keywords
License
Unknown

Abstract

The small subunit (SSU) processome is a 2.2-MDa ribonucleoprotein complex involved in the processing, assembly, and maturation of the SSU of eukaryotic ribosomes. The identities of many of the factors involved in SSU biogenesis have been elucidated over the past 40 years. However, as our understanding increases, so do the number of questions about the nature of this complicated process. Cataloging the components is the first step toward understanding the molecular workings of a system. This review will focus on how identifying components of ribosome biogenesis has led to the knowledge of how these factors, protein and RNA alike, associate with one another into subcomplexes, with a concentration on the small ribosomal subunit. We will also explore how this knowledge of subcomplex assembly has informed our understanding of the workings of the ribosome synthesis system as a whole.

Report this publication

Statistics

Seen <100 times