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Small RNAs in transcriptional gene silencing and genome defence.

Authors
Type
Published Article
Journal
Nature
1476-4687
Publisher
Nature Publishing Group
Publication Date
Volume
457
Issue
7228
Pages
413–420
Identifiers
DOI: 10.1038/nature07756
PMID: 19158787
Source
Medline
License
Unknown

Abstract

Small RNA molecules of about 20-30 nucleotides have emerged as powerful regulators of gene expression and genome stability. Studies in fission yeast and multicellular organisms suggest that effector complexes, directed by small RNAs, target nascent chromatin-bound non-coding RNAs and recruit chromatin-modifying complexes. Interactions between small RNAs and nascent non-coding transcripts thus reveal a new mechanism for targeting chromatin-modifying complexes to specific chromosome regions and suggest possibilities for how the resultant chromatin states may be inherited during the process of chromosome duplication.

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