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Small-molecule fluorescent probes for specific RNA targets.

Authors
  • Murata, Asako
  • Sato, Shin-ichi
  • Kawazoe, Yoshinori
  • Uesugi, Motonari
Type
Published Article
Journal
Chemical Communications
Publisher
The Royal Society of Chemistry
Publication Date
Apr 28, 2011
Volume
47
Issue
16
Pages
4712–4714
Identifiers
DOI: 10.1039/c1cc10393h
PMID: 21412566
Source
Medline
License
Unknown

Abstract

A method was developed that uses small molecules as fluorescent probes to detect specific mRNAs. In this approach, the fluorescence of fluorophore-quencher conjugates is restored by the binding of an mRNA aptamer tag to the quencher segment of the molecules. The method allows real-time detection of mRNA transcripts in vitro.

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