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Small Molecule Enhancers of Endosome-to-Cytosol Import Augment Anti-tumor Immunity

Authors
  • Kozik, Patrycja1, 2
  • Gros, Marine1
  • Itzhak, Daniel N.3
  • Joannas, Leonel1
  • Heurtebise-Chrétien, Sandrine1
  • Krawczyk, Patrycja A.2
  • Rodríguez-Silvestre, Pablo2
  • Alloatti, Andrés1
  • Magalhaes, Joao Gamelas1
  • Del Nery, Elaine4
  • Borner, Georg H.H.3
  • Amigorena, Sebastian1
  • 1 INSERM U932, PSL Research University, Institut Curie, 75005 Paris, France
  • 2 MRC Laboratory of Molecular Biology, Cambridge CB2 0QH, UK
  • 3 Max Planck Institute of Biochemistry, 82152 Martinsried, Germany
  • 4 Institut Curie, PSL Research University, Department of Translational Research-Biophenics High-Content Screening Laboratory, Cell and Tissue Imaging Facility (PICT-IBiSA), 75005 Paris, France
Type
Published Article
Journal
Cell Reports
Publisher
Elsevier
Publication Date
Jul 14, 2020
Volume
32
Issue
2
Identifiers
DOI: 10.1016/j.celrep.2020.107905
PMID: 32668257
PMCID: PMC7370168
Source
PubMed Central
Keywords
License
Unknown

Abstract

Kozik et al. apply a screening strategy to identify drugs that facilitate endosome-to-cytosol import of antigens in dendritic cells during cross-presentation. They characterize selected compounds using proteomic organellar mapping, live-cell imaging, in vitro cross-presentation assays, and tumor models and demonstrate that enhancing import facilitates cross-presentation and synergizes with checkpoint-based immunotherapy.

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