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Small intestinal microbial dysbiosis underlies symptoms associated with functional gastrointestinal disorders

  • Saffouri, George B.1
  • Shields-Cutler, Robin R.2, 3
  • Chen, Jun4
  • Yang, Yi5
  • Lekatz, Heather R.1
  • Hale, Vanessa L.6
  • Cho, Janice M.7
  • Battaglioli, Eric J.1
  • Bhattarai, Yogesh1
  • Thompson, Kevin J.4
  • Kalari, Krishna K.4
  • Behera, Gaurav1
  • Berry, Jonathan C.8
  • Peters, Stephanie A.1
  • Patel, Robin8
  • Schuetz, Audrey N.8
  • Faith, Jeremiah J.9
  • Camilleri, Michael1, 10
  • Sonnenburg, Justin L.11
  • Farrugia, Gianrico12
  • And 4 more
  • 1 Mayo Clinic, Division of Gastroenterology and Hepatology, Rochester, MN, 55902, USA , Rochester (United States)
  • 2 University of Minnesota, BioTechnology Institute, College of Biological Sciences, Minneapolis, MN, 55455, USA , Minneapolis (United States)
  • 3 Macalester College, Department of Biology, Saint Paul, MN, 55105, USA , Saint Paul (United States)
  • 4 Mayo Clinic, Division of Biomedical Statistics and Informatics, Department of Health Sciences Research, Rochester, MN, 55902, USA , Rochester (United States)
  • 5 Imperial College, Computational and Systems Medicine Section of the Department of Surgery and Cancer, (London), UK , (London) (United Kingdom)
  • 6 The Ohio State University, Department of Veterinary Preventive Medicine, Columbus, OH, 43210, USA , Columbus (United States)
  • 7 Mayo Clinic, Division of Internal Medicine, Rochester, MN, 55902, USA , Rochester (United States)
  • 8 Mayo Clinic, Division of Clinical Microbiology, Department of Laboratory Medicine and Pathology, Rochester, MN, 55902, USA , Rochester (United States)
  • 9 Icahn School of Medicine at Mount Sinai, Department of Genetics and Genomic Sciences, Medicine, and Clinical Immunology, New York, NY, 10029, USA , New York (United States)
  • 10 Mayo Clinic, Department of Physiology and Biomedical Engineering, Rochester, MN, 55902, USA , Rochester (United States)
  • 11 Stanford University, Department of Microbiology and Immunology, Stanford, CA, 94305, USA , Stanford (United States)
  • 12 Mayo Clinic, Division of Gastroenterology, Jacksonville, FL, 32224, USA , Jacksonville (United States)
  • 13 University of Minnesota, Department of Computer Science and Engineering, Minneapolis, MN, 55455, USA , Minneapolis (United States)
Published Article
Nature Communications
Springer Nature
Publication Date
May 01, 2019
DOI: 10.1038/s41467-019-09964-7
Springer Nature


Small intestinal bacterial overgrowth (SIBO) has been associated with functional gastrointestinal disorders. Here, the authors show that SIBO may be a result of dietary preferences, and patient symptoms correlate with changes in small intestinal microbial composition but not with SIBO.

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