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Small heat shock proteins in ageing and age-related diseases

Authors
  • Charmpilas, Nikolaos1, 2
  • Kyriakakis, Emmanouil1, 3
  • Tavernarakis, Nektarios1, 4
  • 1 Foundation for Research and Technology-Hellas, Institute of Molecular Biology and Biotechnology, Heraklion, Crete, 70013, Greece , Heraklion (Greece)
  • 2 University of Crete, Department of Biology, Heraklion, Crete, 70013, Greece , Heraklion (Greece)
  • 3 Basel University Hospital and University of Basel, Department of Biomedicine, Laboratory for Signal Transduction, Basel, Switzerland , Basel (Switzerland)
  • 4 University of Crete, Department of Basic Sciences, Faculty of Medicine, Heraklion, Crete, 70013, Greece , Heraklion (Greece)
Type
Published Article
Journal
Cell Stress and Chaperones
Publisher
Springer Netherlands
Publication Date
Jan 10, 2017
Volume
22
Issue
4
Pages
481–492
Identifiers
DOI: 10.1007/s12192-016-0761-x
Source
Springer Nature
Keywords
License
Yellow

Abstract

Small heat shock proteins (sHSPs) are gatekeepers of cellular homeostasis across species, preserving proteome integrity under stressful conditions. Nonetheless, recent evidence suggests that sHSPs are more than molecular chaperones with merely auxiliary role. In contrast, sHSPs have emerged as central lifespan determinants, and their malfunction has been associated with the manifestation of neurological disorders, cardiovascular disease and cancer malignancies. In this review, we focus on the role of sHSPs in ageing and age-associated diseases and highlight the most prominent paradigms, where impairment of sHSP function has been implicated in human pathology.

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