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Influence of Hyperproteinemia on Insect Innate Immune Function of the Circulatory System in Bombyx mori.

Authors
  • Wang, Yong-Feng1, 2
  • Wang, Guang1, 2
  • Li, Jiang-Lan1, 2
  • Qu, Ya-Xin1
  • Liang, Xin-Yin1, 2
  • Chen, Xue-Dong1, 2
  • Sima, Yang-Hu1, 2
  • Xu, Shi-Qing1, 2
  • 1 School of Biology and Basic Medical Sciences, Medical College, Soochow University, Suzhou 215123, China. , (China)
  • 2 Institute of Agricultural Biotechnology & Ecology (IABE), Soochow University, Suzhou 215123, China. , (China)
Type
Published Article
Journal
Biology
Publication Date
Feb 03, 2021
Volume
10
Issue
2
Identifiers
DOI: 10.3390/biology10020112
PMID: 33546519
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Metabolic disorders of the circulatory system of animals (e.g., hyperglycemia and hyperlipidemia) can significantly affect immune function; however, since there is currently no reliable animal model for hyperproteinemia, its effects on immunity remain unclear. In this study, we established an animal model for hyperproteinemia in an invertebrate silkworm model, with a controllable plasma protein concentration (PPC) and no primary disease effects. We evaluated the influence of hyperproteinemia on innate immunity. The results showed that high PPC enhanced hemolymph phagocytosis via inducing a rapid increase in granulocytes. Moreover, while oenocytoids increased, the plasmacytes quickly dwindled. High PPC inhibited hemolymph melanization due to decreased phenoloxidase (PO) activity in the hemolymph via inhibiting the expression of the prophenoloxidase-encoding genes, PPO1 and PPO2. High PPC upregulated the gene expression of antimicrobial peptides via differential activation of the Toll and Imd signaling pathways associated with NF-κB signaling, followed by an induction of inconsistent antibacterial activity towards Gram-positive and Gram-negative bacteria in an animal model of high PPC. Therefore, high PPC has multiple significant effects on the innate immune function of the silkworm circulatory system.

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