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[Slightly active Actinomyces streptomycini (Streptomyces griseus) mutants having a protein in the biosynthesis of the streptidine portion of the streptomycin molecule].

Authors
Type
Published Article
Journal
Antibiotiki
Publication Date
Volume
23
Issue
3
Pages
204–207
Identifiers
PMID: 416747
Source
Medline
License
Unknown

Abstract

Twelve mutants having a block in biosynthesis of the streptidine part of the streptomyciu molecule were selected under the effect of nitrozomethylbiuret. These 12 strains responded by an increase in the level of the antibiotic production to the addition of streptidine to the cultivation medium. The complementation analysis showed that every streptidine-dependent mutant interacted at least with 2 other mutants. On the basis of the data obtained it is possible to conclude that all 12 mutants had blocks in streptidine biosynthesis but at different stages of this complicated process.

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