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Sleeve Gastrectomy in Mice using Surgical Clips.

Authors
  • Wei, Jih-Hua1
  • Yeh, Che-Hung2
  • Lee, Wei-Jei3
  • Lin, Shing-Jong4
  • Huang, Po-Hsun5
  • 1 Cardiovascular Division, Internal Medicine Department, Min-Sheng General Hospital; Department of Nutrition and Health Sciences, School of Healthcare Management, Kai-Nan University; Institute of Clinical Medicine, National Yang-Ming University.
  • 2 Food Science and Biotechnology, College of Biotechnology and Bioresources, University of Da-Yeh.
  • 3 Department of Surgery, Min-Sheng General Hospital.
  • 4 Institute of Clinical Medicine, National Yang-Ming University; Department of Critical Care Medicine, Taipei Veterans General Hospital; Division of Cardiology, Department of Internal Medicine, Taipei Veterans General Hospital; Division of Cardiology, Heart Center, Cheng-Hsin General Hospital; Taipei Medical University.
  • 5 Institute of Clinical Medicine, National Yang-Ming University; Department of Critical Care Medicine, Taipei Veterans General Hospital; Division of Cardiology, Department of Internal Medicine, Taipei Veterans General Hospital; [email protected]
Type
Published Article
Journal
Journal of Visualized Experiments
Publisher
MyJoVE Corporation
Publication Date
Nov 14, 2020
Issue
165
Identifiers
DOI: 10.3791/60719
PMID: 33252113
Source
Medline
Language
English
License
Unknown

Abstract

The number of people who are overweight and obese is continually increasing both in the adult and adolescent populations. This coincides with the increased universal phenomenon of type 2 diabetes (T2D) and other metabolic problems. Bariatric surgery, such as SG, is currently one of the most effective and commonly used long-term treatment for obesity and T2D, but the association between them is not completely explored yet. The mechanisms underlying the outcomes seen after bariatric surgery in humans can be investigated based on preclinical animal studies. The SG reduces body weight, glucose levels and many metabolic parameters, and is easy to perform with a low incidence of complications. The goal of this work is to provide a simple method and an uncomplicated preclinical model of bariatric surgery in animals for researchers.

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