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Sleep problems and their interaction with physical activity and fatigue in hematological cancer patients during onset of high dose chemotherapy.

Authors
  • Castelli, Lucia1
  • Elter, Thomas2
  • Wolf, Florian3
  • Watson, Matthew4
  • Schenk, Alexander5
  • Steindorf, Karen6
  • Bloch, Wilhelm3
  • Hallek, Michael2
  • Joisten, Niklas5
  • Zimmer, Philipp7
  • 1 Department of Biomedical Sciences for Health, University of Milan, Via Giuseppe Colombo 71, 20133, Milan, Italy. , (Italy)
  • 2 Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf, University of Cologne, Kerpener Straße 62, 50937, Cologne, Germany. , (Germany)
  • 3 Department of Molecular and Cellular Sports Medicine, Institute of Cardiovascular Research and Sports Medicine, German Sport University Cologne, Am Sportpark Müngersdorf 6, 50933, Cologne, Germany. , (Germany)
  • 4 Institute of Psychology, German Sport University Cologne, Am Sportpark Müngersdorf 6, 50933, Cologne, Germany. , (Germany)
  • 5 Division for Performance and Health (Sports Medicine), Institute for Sport and Sport Science, TU Dortmund University, Otto-Hahn-Straße, 344227, Dortmund, Germany. , (Germany)
  • 6 Division of Physical Activity, Prevention and Cancer, German Cancer Research Center (DKFZ), National Center for Tumor Diseases (NCT) Heidelberg, Im Neuenheimer Feld 460, 69120, Heidelberg, Germany. , (Germany)
  • 7 Division for Performance and Health (Sports Medicine), Institute for Sport and Sport Science, TU Dortmund University, Otto-Hahn-Straße, 344227, Dortmund, Germany. [email protected] , (Germany)
Type
Published Article
Journal
Supportive Care in Cancer
Publisher
Springer-Verlag
Publication Date
Jan 01, 2022
Volume
30
Issue
1
Pages
167–176
Identifiers
DOI: 10.1007/s00520-021-06377-5
PMID: 34245360
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Sleep problems reported by hematological cancer patients are usually linked to higher levels of cancer-related fatigue. Although the awareness of sleep problems in solid cancer patients is rising, there has been less attention to the issue in hematological cancer patients. The present study assesses the differences in sleep by comparing physical activity and fatigue levels among hematological cancer patients during the onset of chemotherapy. Furthermore, it investigates the relationship between sleep, physical activity, and fatigue through mediation analysis. The recruited sample consists of 58 newly diagnosed hematological cancer patients (47.1 ± 15.4 yrs; 51.7% males). Subjects completed questionnaires assessing sleep (PSQI), physical activity (visual analogue scale), fatigue (MFI-20), anxiety, depression (HADS), and quality of life (EORTC QLQ-C30) within two weeks from starting treatment. The sample reported more sleep problems in comparison to the German population norm. The classification as good (ca 25%) or bad sleepers (ca 75%) showed less frequent physical activity (p = .04), higher fatigue (p = .032), anxiety (p = .003), depression (p = .011) and pain (p = .011) in bad sleepers. The mediation analysis revealed significant indirect effects of sleep on fatigue through physical activity habits. This study highlights the combined action of sleep problems and physical activity on fatigue during the onset of induction chemotherapy. These two parameters could represent meaningful intervention targets to improve a patient's status during chemotherapy. The study was registered on the WHO trial register (DRKS00007824). © 2021. The Author(s).

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