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Sleep duration and napping in relation to colorectal and gastric cancer in the MCC-Spain study

Authors
  • Papantoniou, Kyriaki1, 2
  • Castaño-Vinyals, Gemma2, 3, 4, 5
  • Espinosa, Ana2, 3, 4, 5
  • Turner, Michelle C.2, 3, 4, 6
  • Martín-Sánchez, Vicente4, 7
  • Casabonne, Delphine4, 8
  • Aragonés, Nuria4, 9
  • Gómez-Acebo, Inés4, 10, 11
  • Ardanaz, Eva4, 12, 13
  • Jimenez-Moleon, Jose-Juan4, 14, 15
  • Amiano, Pilar4, 16, 17
  • Molina-Barceló, Ana18
  • Alguacil, Juan4, 19
  • Fernández-Tardón, Guillermo4, 20
  • Huerta, José María4, 21
  • Hernández-Segura, Natalia7
  • Perez-Gomez, Beatriz4, 22, 23
  • Llorca, Javier4, 10
  • Vidán-Alli, Juana4, 12, 13
  • Olmedo-Requena, Rocıo4, 14, 15
  • And 5 more
  • 1 Medical University of Vienna, Kinderspitalgasse 15, Vienna, 1090, Austria , Vienna (Austria)
  • 2 ISGlobal, Barcelona, Spain , Barcelona (Spain)
  • 3 Universitat Pompeu Fabra (UPF), Barcelona, Spain , Barcelona (Spain)
  • 4 Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), Madrid, Spain , Madrid (Spain)
  • 5 IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain , Barcelona (Spain)
  • 6 University of Ottawa, Ottawa, ON, Canada , Ottawa (Canada)
  • 7 University of León, Leon, Spain , Leon (Spain)
  • 8 IDIBELL, Catalan Institute of Oncology, Hospitalet de Llobregat, Barcelona, Spain , Barcelona (Spain)
  • 9 Department of Health of Madrid, Madrid, Spain , Madrid (Spain)
  • 10 University of Cantabria, Santander, Spain , Santander (Spain)
  • 11 IDIVAL, Santander, Spain , Santander (Spain)
  • 12 Navarra Public Health Institute, Pamplona, Spain , Pamplona (Spain)
  • 13 Navarra Institute for Health Research, Pamplona, Spain , Pamplona (Spain)
  • 14 University of Granada, Granada, Spain , Granada (Spain)
  • 15 Hospitales Universitarios de Granada/Universidad de Granada, Granada, Spain , Granada (Spain)
  • 16 Public Health Division of Gipuzkoa, San Sebastian, Spain , San Sebastian (Spain)
  • 17 Biodonostia Research Institute, San Sebastian, Spain , San Sebastian (Spain)
  • 18 FISABIO-Public Health, Valencia, Spain , Valencia (Spain)
  • 19 Universidad de Huelva, Campus Universitario de El Carmen, Huelva, Spain , Huelva (Spain)
  • 20 University of Oviedo, Oviedo, Spain , Oviedo (Spain)
  • 21 Murcia Regional Health Council, IMIB-Arrixaca, Murcia, Spain , Murcia (Spain)
  • 22 Carlos III Institute of Health, Madrid, Spain , Madrid (Spain)
  • 23 IIS Puerta de Hierro (IDIPHIM), Majadahonda, Madrid, Spain , Madrid (Spain)
  • 24 Complejo Asistencial Universitario de León, Leon, Spain , Leon (Spain)
  • 25 Catalan Institute of Oncology (ICO), Hospitalet de Llobregat, Barcelona, Spain , Barcelona (Spain)
  • 26 Bellvitge Biomedical Research Institute (IDIBELL), Hospitalet de Llobregat, Barcelona, Spain , Barcelona (Spain)
  • 27 University of Barcelona, Barcelona, Spain , Barcelona (Spain)
Type
Published Article
Journal
Scientific Reports
Publisher
Springer Nature
Publication Date
Jun 03, 2021
Volume
11
Issue
1
Identifiers
DOI: 10.1038/s41598-021-91275-3
Source
Springer Nature
License
Green

Abstract

Sleep duration is a novel and potentially modifiable risk factor for cancer. We evaluated the association of self-reported sleep duration and daytime napping with odds of colorectal and gastric cancer. We included 2008 incident colorectal cancer cases, 542 gastric cancer cases and 3622 frequency-matched population controls, recruited in the MCC-Spain case–control study (2008–2013). Sleep information, socio-demographic and lifestyle characteristics were obtained through personal interviews. Multivariable adjusted logistic regression models were used to estimate odds ratios (OR) with 95% confidence intervals (CI) for cancer, across categories of sleep duration (≤ 5, 6, 7, 8, ≥ 9 hours/day), daytime napping frequency (naps/week) and duration (minutes/nap). Compared to 7 hours of sleep, long sleep was associated with increased odds of colorectal (OR≥9 hours: 1.59; 95%CI 1.30–1.94) and gastric cancer (OR≥9 hours: 1.95; 1.37–2.76); short sleep was associated with increased odds of gastric cancer (OR≤5 hours: 1.32; 0.93–1.88). Frequent and long daytime naps increased the odds of colorectal (OR6–7 naps/week, ≥30 min: 1.32; 1.14–1.54) and gastric cancer (OR6–7 naps/week, ≥30 min: 1.56; 1.21–2.02). Effects of short sleep and frequent long naps were stronger among participants with night shift-work history. Sleep and circadian disruption may jointly play a role in the etiology of colorectal and gastric cancer.

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