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Sleep apnea is induced by a high-fat diet and reversed and prevented by metformin in non-obese rats.

Authors
  • Ramadan, Wiâm
  • Dewasmes, Gérard
  • Petitjean, Michel
  • Wiernsperger, Nicolas
  • Delanaud, Stéphane
  • Geloen, Alain
  • Libert, Jean-Pierre
Type
Published Article
Journal
Obesity (Silver Spring, Md.)
Publication Date
Jun 01, 2007
Volume
15
Issue
6
Pages
1409–1418
Identifiers
PMID: 17557978
Source
Medline
License
Unknown

Abstract

Insulin resistance induced by the HF diet could be the promoter of sleep apnea in non-obese rats. Metformin is an efficient curative and preventive treatment for sleep apnea, suggesting that insulin resistance modifies the ventilatory drive independently of obesity.

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