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Skp2, the FoxO1 hunter.

Authors
  • Dehan, Elinor
  • Pagano, Michele
Type
Published Article
Journal
Cancer Cell
Publisher
Elsevier
Publication Date
Mar 01, 2005
Volume
7
Issue
3
Pages
209–210
Identifiers
PMID: 15766658
Source
Medline
License
Unknown

Abstract

Skp2 is an oncoprotein that mediates the degradation of several negative regulators of the cell cycle to promote cell proliferation. A recent report by Huang and colleagues reveals that Skp2 directs the ubiquitylation and subsequent degradation of FoxO1, a member of the FoxO family of transcription factors. Since FoxO proteins possess tumor suppressor functions, this new finding suggests a new mechanism by which Skp2 may favor tumorigenesis.

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