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Skewed X chromosome inactivation in diploid and triploid female human embryonic stem cells.

Authors
  • Liu, Weiqiang
  • Sun, Xiaofang
Type
Published Article
Journal
Human Reproduction
Publisher
Oxford University Press
Publication Date
Aug 01, 2009
Volume
24
Issue
8
Pages
1834–1843
Identifiers
DOI: 10.1093/humrep/dep126
PMID: 19429659
Source
Medline
License
Unknown

Abstract

Two types of XCI pattern were found in the female hESCs used in this study. Most hESCs fell into one category where the XCI pattern is extremely skewed, although the other category includes hESCs with random XCI. The XCI pattern in a triploid hESC line varies gradually and eventually reaches an extremely skewed XCI pattern after long-term culture. Our study demonstrates that there is a large variability in terms of X inactivation among hESC lines, and even at different passages of the same line.

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