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Skeletal muscle satellite cells: mediators of muscle growth during development and implications for developmental disorders.

Authors
  • Dayanidhi, Sudarshan
  • Lieber, Richard L
Type
Published Article
Journal
Muscle & Nerve
Publisher
Wiley (John Wiley & Sons)
Publication Date
Nov 01, 2014
Volume
50
Issue
5
Pages
723–732
Identifiers
DOI: 10.1002/mus.24441
PMID: 25186345
Source
Medline
Keywords
License
Unknown

Abstract

Satellite cells (SCs) are the muscle stem cells responsible for longitudinal and cross-sectional postnatal growth and repair after injury and which provide new myonuclei when needed. We review their morphology and contribution to development and their role in sarcomere and myonuclear addition. SCs, similar to other tissue stem cells, cycle through different states, such as quiescence, activation, and self-renewal, and thus we consider the signaling mechanisms involved in maintenance of these states. The role of the SC niche and their interactions with other cells, such as fibroblasts and the extracellular matrix, are all emerging as major factors that affect aging and disease. Interestingly, children with cerebral palsy appear to have a reduced SC number, which could play a role in their reduced muscular development and even in muscular contracture formation. Finally, we review the current information on SC dysfunction in children with muscular dystrophy and emerging therapies that target promotion of myogenesis and reduction of fibrosis.

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