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Skeletal muscle as an experimental model of choice to study tissue aging and rejuvenation

Authors
  • Etienne, Jessy1
  • Liu, Chao1
  • Skinner, Colin M.1
  • Conboy, Michael J.1
  • Conboy, Irina M.1
  • 1 University of California, Berkeley, Berkeley, CA, 94720-3220, USA , Berkeley (United States)
Type
Published Article
Journal
Skeletal Muscle
Publisher
Springer (Biomed Central Ltd.)
Publication Date
Feb 07, 2020
Volume
10
Issue
1
Identifiers
DOI: 10.1186/s13395-020-0222-1
Source
Springer Nature
Keywords
License
Green

Abstract

Skeletal muscle is among the most age-sensitive tissues in mammal organisms. Significant changes in its resident stem cells (i.e., satellite cells, SCs), differentiated cells (i.e., myofibers), and extracellular matrix cause a decline in tissue homeostasis, function, and regenerative capacity. Based on the conservation of aging across tissues and taking advantage of the relatively well-characterization of the myofibers and associated SCs, skeletal muscle emerged as an experimental system to study the decline in function and maintenance of old tissues and to explore rejuvenation strategies. In this review, we summarize the approaches for understanding the aging process and for assaying the success of rejuvenation that use skeletal muscle as the experimental system of choice. We further discuss (and exemplify with studies of skeletal muscle) how conflicting results might be due to variations in the techniques of stem cell isolation, differences in the assays of functional rejuvenation, or deciding on the numbers of replicates and experimental cohorts.

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