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Skeletal Muscle Atrophy in Men with Chronic Alcoholic Myopathy (impairment to signal pathways)

Authors
  • Shenkman, B. S.1
  • Zinovyeva, O. E.2
  • Belova, S. P.1
  • Mirzoev, T. M.1
  • Vilchinskaya, N. A.1
  • Turtikova, O. V.1
  • Nemirovskaya, T. L.1, 3
  • 1 Institute of Medical-Biological Problems, Russian Academy of Sciences, Moscow, Russia , Moscow (Russia)
  • 2 Sechenov First Moscow State Medical University, Moscow, Russia , Moscow (Russia)
  • 3 Lomonosov Moscow State University, Moscow, Russia , Moscow (Russia)
Type
Published Article
Journal
Neuroscience and Behavioral Physiology
Publisher
Springer US
Publication Date
Apr 26, 2019
Volume
49
Issue
4
Pages
490–494
Identifiers
DOI: 10.1007/s11055-019-00760-w
Source
Springer Nature
Keywords
License
Yellow

Abstract

The main effect of chronic alcoholic myopathy is atrophy of fast muscle fibers (18 years of alcohol abuse), followed by slow fibers (31 years of alcohol abuse); plasma IGF-1 levels decrease and muscle IRS-1 and p-p70S6k decrease, which is evidence for suppression of the functioning of the mTORC1 signal pathway and reductions in protein synthesis. Patients show increases in the expression of mRNA encoding HSP90/70, which can lead to increases in the protection of proteins from degradation. All patients showed increased expression of E3 ligase, which is evidence for an increase in the operation of the ubiquitin-proteasomal signal pathway for protein degradation.

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