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Size-Controlled Preparation and Behavior Study of Phospholipid–Calcium Carbonate Hybrid Nanoparticles

Authors
  • Wang, Cheng1
  • Chen, Shaoqing1
  • Bao, Lu1
  • Liu, Xuerong1
  • Hu, Fuqiang1
  • Yuan, Hong1
  • 1 College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058
Type
Published Article
Journal
International Journal of Nanomedicine
Publisher
Dove Medical Press
Publication Date
Jun 09, 2020
Volume
15
Pages
4049–4062
Identifiers
DOI: 10.2147/IJN.S237156
PMID: 32606663
PMCID: PMC7293410
Source
PubMed Central
Keywords
License
Green

Abstract

Background Calcium carbonate (CC) nanoparticles have broad biomedical utilizations, owing to their multiple intrinsic merits. However, bare CC nanoparticles do not allow for the development of multifunctional devices suitable for advanced drug delivery in cancer therapy. Methods Phospholipid-modified phospholipid–CC hybrid nanoparticles were prepared in our study using a combination of vapor-diffusion and solvent-diffusion methods to offer optimized pharmaceutical capabilities. Results Considering that particle size is a critical parameter that plays an important role in both in vitro and in vivo behaviors of nanoparticles, we here for the first time a present detailed protocol for the size-controlled preparation of hybrid nanoparticles, as well as analysis of the in vitro/in vivo behaviors of differently sized hybrid nanoparticles. Conclusion Our results might significantly advance the application of this promising material in more varied fields.

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