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In situ reprogramming of gut bacteria by oral delivery

Authors
  • Hsu, Bryan B.1, 2, 3
  • Plant, Isaac N.2, 3
  • Lyon, Lorena2, 3
  • Anastassacos, Frances M.3, 2
  • Way, Jeffrey C.2, 3, 2
  • Silver, Pamela A.2, 3
  • 1 Virginia Tech, Blacksburg, VA, 24061, USA , Blacksburg (United States)
  • 2 Harvard Medical School, Boston, MA, 02115, USA , Boston (United States)
  • 3 Harvard University, Boston, MA, 02115, USA , Boston (United States)
Type
Published Article
Journal
Nature Communications
Publisher
Springer Nature
Publication Date
Oct 06, 2020
Volume
11
Issue
1
Identifiers
DOI: 10.1038/s41467-020-18614-2
Source
Springer Nature
License
Green

Abstract

It is difficult to precisely target bacterial populations in the mammalian gut. Here the authors use encapsulated phages to deliver dCas9 to E. coli in the mouse gut to modulate RFP expression.

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