In situ quantitation of pancuronium bromide and hydrolysis products by spectrodensitometry of thin-layer chromatograms

A method is described for densitometric evaluation of pancuronium and hydrolysis products, separated by thin layer chromatography. By adaptation of the detection procedure, iodine vapour can be used as visualization reagent. Quantitative determination in relative amounts is possible, because the desorption process of iodine from the spots follows a first order reaction. Precision and accuracy of the method are acceptable. / status: published