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Site of H Atom Attack on Uracil and Its Derivatives in Aqueous Solution

Authors
  • Das, Suresh
  • Deeble, David J.
  • Sonntag, Clemens von
Type
Published Article
Journal
Zeitschrift für Naturforschung C
Publisher
Walter de Gruyter GmbH
Publication Date
Apr 01, 1985
Volume
40
Issue
3-4
Pages
292–294
Identifiers
DOI: 10.1515/znc-1985-3-425
Source
De Gruyter
Keywords
License
Green

Abstract

Hydrogen atoms from the radiolysis of water at pH 1.6 add to the 5,6-double bond of pyrimidines. The preferen­tial site of attack is the C(5) position (values in brackets) in the case of 6-methyluracil (87%), 1,3-dimethyluracil (71%), uracil (69%) and poly(U) (60%). This reaction yields a radical of reducing properties which can be monitored by its reaction with tetranitromethane in a pulse radiolysis experiment. In thymine (37%), thymidine (32%) and 1,3-dimethylthymine (25%) H-addition no longer pre­ferentially occurs at C(5), but addition is now mainly at C(6). Hydrogen abstraction from the methyl groups or the sugar moiety is negligible (≦ 5.5%). A comparison is made with literature values for the equivalent reactions of OH radicals.

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