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Sister chromatid exchange analysis in lymphocytes of workers exposed to hexavalent chromium.

Authors
Type
Published Article
Journal
British journal of industrial medicine
Publication Date
Volume
46
Issue
1
Pages
48–51
Identifiers
PMID: 2920143
Source
Medline
License
Unknown

Abstract

To investigate the usefulness of sister chromatid exchange (SCE) analysis in lymphocytes as an indicator for mutagenic effects after in vivo exposure to hexavalent chromium (Cr), SCE frequency was analysed in lymphocytes of 44 Cr platers occupationally exposed to hexavalent Cr and 47 controls. Although urinary Cr analysis confirmed that the Cr platers were exposed to Cr, no effects of the exposure on SCE frequency were found. Smokers, both Cr platers and controls, had a significantly higher SCE frequency than non-smokers. These results suggest that SCE analysis in human lymphocytes is not a good indicator of possible mutagenic effects of exposure to hexavalent Cr.

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