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Sister chromatid exchange analysis in lung and peripheral blood lymphocytes of mice exposed to methyl isocyanate by inhalation.

Authors
  • Kligerman, A D
  • Campbell, J A
  • Erexson, G L
  • Allen, J W
  • Shelby, M D
Type
Published Article
Journal
Environmental mutagenesis
Publication Date
Jan 01, 1987
Volume
9
Issue
1
Pages
29–36
Identifiers
PMID: 3803323
Source
Medline
License
Unknown

Abstract

Mice were exposed to 1, 3, or 6 ppm methyl isocyanate (MIC) for 6 hr/day for four consecutive days. Lung cells and peripheral blood lymphocytes (PBLs) were removed and cultured for analysis of sister chromatid exchange (SCE) and cell cycle kinetics. MIC caused a small but significant increase in SCE frequency of cultured lung cells from mice exposed to 1, 3, or 6 ppm MIC. MIC did not significantly increase SCE levels in PBLs of mice exposed to concentrations as high as 6 ppm. In cultured PBLs, MIC had a stimulatory effect on cell cycling rates as measured by the replicative index, and it caused a significant reduction in mononuclear leucocyte counts and the mitotic indices.

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