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SIRT1 metabolic actions: Integrating recent advances from mouse models

Authors
  • Boutant, Marie
  • Cantó, Carles1
  • 1 Nestlé Institute of Health Sciences S.A.
Type
Published Article
Journal
Molecular Metabolism
Publisher
Elsevier BV
Publication Date
Jan 01, 2013
Accepted Date
Oct 17, 2013
Volume
3
Issue
1
Pages
5–18
Identifiers
DOI: 10.1016/j.molmet.2013.10.006
Source
Elsevier
Keywords
License
Unknown

Abstract

SIRT1 has attracted a lot of interest since it was discovered as a mammalian homolog of Sir2, a protein that influences longevity in yeast. Intensive early research suggested a key role of SIRT1 in mammalian development, metabolic flexibility and oxidative metabolism. However, it is the growing body of transgenic models that are allowing us to clearly define the true range of SIRT1 actions. In this review we aim to summarize the most recent lessons that transgenic animal models have taught us about the role of SIRT1 in mammalian metabolic homeostasis and lifespan.

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